Molecular insights into α2 adrenergic receptor function: clinical implications

Efferent signaling from the sympathetic nervous system integrates myriad vital functions. Modulation of sympathetic neuron signaling occurs in part by feedback inhibition of neurotransmitter release, mediated largely via α2a and/or α2c adrenergic receptors (α2a&c ARs). This review will describe an overview of our current understanding of α2a&c AR biology, clinical implications of these findings, and the possible clinical importance of genetic variants of α2a&c ARs.