The Evolution of Adult-Onset Still Disease: An Observational and Comparative Study in a Cohort of 76 Italian Patients

ObjectivesAdult-onset Still's disease (AOSD) is a potentially crippling or life-threatening rare disease that may be self-limited, intermittent, and chronic. Clinical predictors of outcome are still lacking, as is information on the rate of progress of its chronic course. The main objective is to identify factors that improve our ability to predict the course of AOSD, and factors associated with the rate of progress of its chronic course. A comparison with the literature is included.MethodsA retrospective cohort observational study conducted at the tertiary-referral Rheumatology Unit in Ferrara, Italy.ResultsSeventy-six patients (44 females and 32 males) referred to the Unit and who satisfied the criteria for AOSD were identified. Our findings on white AOSD patients are largely compatible with those previously published. Ferritin level, as well disease activity score (DAS28), is associated with the rate of progression of the articular manifestations of the disease. A polyarthritis persisting over 6 months is associated with the development of a chronic articular course, irrespective of the size of the involved joints.ConclusionsFerritin, being associated with the course of AOSD, could play a role in the diagnosis of the disease. Together with DAS28, it might also serve as a useful predictor for the rate of progress of the chronic course of the disease, as measured with simple erosion narrowing score.