کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2771809 | 1151774 | 2010 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Anakinra's Efficacy is Variable in Refractory Gout: Report of Ten Cases Anakinra's Efficacy is Variable in Refractory Gout: Report of Ten Cases](/preview/png/2771809.png)
ObjectivesTo evaluate the efficacy of anakinra for patients with acute gout.MethodsWe reviewed the charts of 10 patients who received anakinra for urate crystal-induced arthritis at the Hospital for Special Surgery since 2007. Demographic information, comorbidities, short-term treatment outcomes, and subsequent flares were reviewed.ResultsPatients in our study had a high prevalence of comorbidities. All patients received corticosteroids before anakinra treatment. The mean number of anakinra injections was 3.2 per patient (100 mg subcutaneously per day). Six patients had a good response. Three patients had a partial response and 1 patient had no response. Nine patients had documented recurrent flares after discontinuing anakinra (ranging from 3 to 45 days after).ConclusionAnakinra is a therapeutic option for patients with acute urate crystal-induced arthritis who do not respond to or have a contraindication to traditional treatments. Although a short course of anakinra resulted in favorable outcomes for some of our patients, response rates were poorer in our study than in previously published reports, and relapses were common.
Journal: Seminars in Arthritis and Rheumatism - Volume 40, Issue 3, December 2010, Pages 210–214