کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2771831 | 1151775 | 2008 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Wegener Granulomatosis with Spleen Infarction: Case Report and Review of the Literature Wegener Granulomatosis with Spleen Infarction: Case Report and Review of the Literature](/preview/png/2771831.png)
ObjectiveTo report a case of biopsy-verified Wegener granulomatosis (WG) with positive c-antineutrophil cytoplasmic antibodies who had evidence of spleen infarction and to review the relevant literature on spleen involvement in WG.MethodsDescriptive case report of 1 patient with WG complicated by spleen infarction and review of the relevant literature (PubMed search 1966 through February 2007).ResultsIn our patient spleen involvement (infarction) was clinically silent and was incidentally detected on the caudal slides of a chest computed tomography (CT) performed to investigate pulmonary involvement. Similar cases have been reported: in the published literature reviewed, overall 18 patients have been described and other cases have been described after autopsy. Of these, 8 patients were symptomatic: generally, they complained of diffuse or left upper quadrant abdominal pain. In 15 patients, spleen involvement was detected by ultrasound, scintigraphy, CT scan, or magnetic resonance imaging. In 1 case only was the diagnosis confirmed by biopsy (after splenectomy).ConclusionsThe frequency of spleen infarction is probably underestimated in WG since it is often clinically silent as in our patient. In addition to spleen infarction, WG has also been implicated in inducing spleen hemorrhage, capsular adhesions, dysfunction, and splenomegaly. Since some of the spleen lesions may lead to complications, a high index of suspicion should be maintained for spleen involvement in patients with WG, particularly in the presence of abdominal symptoms.
Journal: Seminars in Arthritis and Rheumatism - Volume 37, Issue 5, April 2008, Pages 328–333