کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2773100 1567897 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Blood metabolomics analysis identifies abnormalities in the citric acid cycle, urea cycle, and amino acid metabolism in bipolar disorder
ترجمه فارسی عنوان
تجزیه و تحلیل متابولومیک خون شناسایی اختلالات در چرخه اسید سیتریک، چرخه اوره و متابولیسم اسید آمینه در اختلال دوقطبی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
چکیده انگلیسی


• Metabolomics analysis of serum sample from bipolar disorder (BD) was performed.
• Pyruvate, N-acetylglutamic acid, α-ketoglutarate, and arginine were higher in BD.
• β-alanine, and serine were lower in BD patients.
• Abnormalities in citric acid cycle, urea cycle, and amino acid metabolism in BD.

BackgroundBipolar disorder (BD) is a severe and debilitating psychiatric disorder. However, the precise biological basis remains unknown, hampering the search for novel biomarkers. We performed a metabolomics analysis to discover novel peripheral biomarkers for BD.MethodsWe quantified serum levels of 116 metabolites in mood-stabilized male BD patients (n = 54) and age-matched male healthy controls (n = 39).ResultsAfter multivariate logistic regression, serum levels of pyruvate, N-acetylglutamic acid, α-ketoglutarate, and arginine were significantly higher in BD patients than in healthy controls. Conversely, serum levels of β-alanine, and serine were significantly lower in BD patients than in healthy controls. Chronic (4-weeks) administration of lithium or valproic acid to adult male rats did not alter serum levels of pyruvate, N-acetylglutamic acid, β-alanine, serine, or arginine, but lithium administration significantly increased serum levels of α-ketoglutarate.ConclusionsThe metabolomics analysis demonstrated altered serum levels of pyruvate, N-acetylglutamic acid, β-alanine, serine, and arginine in BD patients.General significanceThe present findings suggest that abnormalities in the citric acid cycle, urea cycle, and amino acid metabolism play a role in the pathogenesis of BD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: BBA Clinical - Volume 5, June 2016, Pages 151–158
نویسندگان
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