Diagnóstico bioquímico del exceso de secreción de somatotropina (I)

To correctly evaluate the results of laboratory tests, variables such as sex, age, body mass index, and the presence of associated diseases should be taken into account. Also of relevance are variability in laboratory results, due to the heterogeneity of the molecule, the type of antibodies used in the immunoassay, the standardization of the method, and the interference of the GH binding protein. The cut-off values used to rule out the presence of acromegaly or as criteria for monitoring and treatment of the disease were established by consensus in 2000. However, these values have been questioned due to the sensitivity and specificity of modern immunoassays.