کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2774716 | 1152247 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pubertad precoz
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کلمات کلیدی
Gonadotropin releasing hormone analoguesPeripheral precocious pubertyEtiología - اتیولوژیAdverse effects - اثرات جانبیPrecocious puberty - بلوغ زودرسPubertad precoz - بلوغ زودرسCentral precocious puberty - بلوغ زودرس بلوغTreatment - درمانTratamiento - درمان Etiology - سببشناسی یا اتیولوژیEfectos secundarios - عوارض جانبی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Pubertad precoz Pubertad precoz](/preview/png/2774716.png)
چکیده انگلیسی
In Europe precocious puberty is defined as the presence of secondary sexual characteristics before the age of 8 in girls and before the age of 9 in boys. Central precocious puberty (CPP) depends on gonadotropin releasing hormone (GnRH) and is associated with high levels of gonadotropins and sexual steroids. The order of appearance of secondary sexual characteristics is identical to that in physiological puberty. Growth velocity and bone maturity are increased. Most cases in girls are idiopathic but more than half of cases in boys are due to organic disease. Peripheral precocious puberty (PPP) is independent of GnRH and shows high levels of sexual steroids and gonadotropin inhibition. To establish a diagnosis of PPP, various imaging and laboratory studies are required. In CPP, treatment consists of GnRH analogues that inhibit gonadotropin secretion and lead to regression of sexual maturity. However, this treatment has little effect on pubic hair. Both growth velocity and bone maturity diminish, which improves final height. GnRH analogues are an effective treatment with no long-term adverse effects. Most authors recommend stopping treatment when bone age is about 12 years. Menarche occurs approximately 6-18 months after treatment withdrawal. In early puberty, treatment does not improve final height. In PPP, treatment and followup differ, depending on the etiology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: EndocrinologÃa y Nutrición - Volume 54, Issue 5, May 2007, Pages 259-264
Journal: EndocrinologÃa y Nutrición - Volume 54, Issue 5, May 2007, Pages 259-264
نویسندگان
Amaia Vela Desojo, Pedro Martul TobÃo, Itxaso Rica EtxebarrÃa, AnÃbal Aguayo Calcenas,