Finding mouse models of human lymphomas and leukemia's using the Jackson laboratory mouse tumor biology database

• The Mouse Tumor Biology (MTB)Database curates detailed information on mouse lymphomas.
• MTB provides query mechanisms to access lymphoma and other tumor type data.
• MTB enhances these data by providing 51 Whole-slide scans of 23 lymphomas.
• MTB provides detailed histopathological and immunohistochemical slide annotations.
• New resource to assist investigators at properly defining mouse lymphoma type.

Many mouse models have been created to study hematopoietic cancer types. There are over thirty hematopoietic tumor types and subtypes, both human and mouse, with various origins, characteristics and clinical prognoses. Determining the specific type of hematopoietic lesion produced in a mouse model and identifying mouse models that correspond to the human subtypes of these lesions has been a continuing challenge for the scientific community. The Mouse Tumor Biology Database (MTB; http://tumor.informatics.jax.org) is designed to facilitate use of mouse models of human cancer by providing detailed histopathologic and molecular information on lymphoma subtypes, including expertly annotated, on line, whole slide scans, and providing a repository for storing information on and querying these data for specific lymphoma models.