کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2775017 1152305 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Soluble CD163 is increased in patients with acute pancreatitis independent of disease severity
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
Soluble CD163 is increased in patients with acute pancreatitis independent of disease severity
چکیده انگلیسی


• Soluble CD163 is increased in acute pancreatitis.
• Levels are not associated with disease severity.
• Levels do not correlate with C-reactive protein.
• Levels are not associated with complications.

Macrophages are crucially involved in the pathophysiology of acute pancreatitis. Soluble CD163 (sCD163) is specifically released from macrophages and systemic levels are increased in inflammatory diseases. Here, sCD163 was measured in serum of 50 patients with acute pancreatitis to find out possible associations with disease activity. Admission levels of systemic sCD163 were nearly three-fold higher in patients with acute pancreatitis compared to controls. In patients sCD163 did not correlate with C-reactive protein and leukocyte count as established markers of inflammation. Levels were not associated with disease severity assessed by the Schroeder score, Balthazar score, Acute Physiology, Age, and Chronic Health Evaluation (Apache) II score and peripancreatic necrosis score. Soluble CD163 was not related to complications of acute pancreatitis. These data show that serum sCD163 is increased in acute pancreatitis indicating activation of macrophages but is not associated with disease severity and outcome.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental and Molecular Pathology - Volume 99, Issue 2, October 2015, Pages 236–239
نویسندگان
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