کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2775035 | 1152305 | 2015 | 5 صفحه PDF | دانلود رایگان |

• Arsenic regulates immune response through AATF genome.
• Arsenic regulates T-cell plasticity.
• Arsenic regulates effector class switching through miR-2909.
Arsenic biology has caught the imagination of scientists across the globe because of its unique association with degenerative diseases in general and cancer in particular. Recent findings have added a new dimension to arsenic biology by revealing that most of the arsenic epigenomic effects are mediated through its ability to induce cellular miR-2909 expression at low doses. The present study was addressed to explore the molecular link that might exist between arsenic exposure, miR-2909 RNomics involving immunomodulatory genes and effector IgA class switching, revealed that arsenic-exposed Balb/c mice exhibited predominant Th1 immune response coupled with effector IgA class switching thereby tailoring their immune system to ensure increased risk to infections and chronic diseases like cancer.
Journal: Experimental and Molecular Pathology - Volume 99, Issue 2, October 2015, Pages 360–364