کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2775035 1152305 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Arsenic toxi-RNomics has the ability to tailor the host immune response
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
Arsenic toxi-RNomics has the ability to tailor the host immune response
چکیده انگلیسی


• Arsenic regulates immune response through AATF genome.
• Arsenic regulates T-cell plasticity.
• Arsenic regulates effector class switching through miR-2909.

Arsenic biology has caught the imagination of scientists across the globe because of its unique association with degenerative diseases in general and cancer in particular. Recent findings have added a new dimension to arsenic biology by revealing that most of the arsenic epigenomic effects are mediated through its ability to induce cellular miR-2909 expression at low doses. The present study was addressed to explore the molecular link that might exist between arsenic exposure, miR-2909 RNomics involving immunomodulatory genes and effector IgA class switching, revealed that arsenic-exposed Balb/c mice exhibited predominant Th1 immune response coupled with effector IgA class switching thereby tailoring their immune system to ensure increased risk to infections and chronic diseases like cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental and Molecular Pathology - Volume 99, Issue 2, October 2015, Pages 360–364
نویسندگان
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