کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2775253 1152318 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immunohistochemical detection of a specific receptor for lipocalin2 (solute carrier family 22 member 17, SLC22A17) and its prognostic significance in endometrial carcinoma
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
Immunohistochemical detection of a specific receptor for lipocalin2 (solute carrier family 22 member 17, SLC22A17) and its prognostic significance in endometrial carcinoma
چکیده انگلیسی

BackgroundWe previously reported the overexpression of lipocalin2 (LCN2), a 25 kDa secretory protein involved in iron-transportation, in endometrial carcinoma and its possible contribution to endometrial carcinogenesis. Recently, a specific receptor for LCN2, solute carrier family 22 member 17 (SLC22A17), was identified. The present study was undertaken to investigate the expression of SLC22A17 in endometrial carcinoma.MethodsThe expression of the SLC22A17 and LCN2 proteins was examined immunohistochemically using 69 cases of endometrial carcinoma and adjacent normal endometrial tissues. Immunoreactivity was evaluated according to the percentage of positive cells and described as a positivity index (PI, full score 100).ResultsThe expression of SLC22A17 was negligible in normal endometria, but positive staining for SLC22A17 (PI ≧ 1) was observed in 35 cases of endometrial carcinoma. The PI for SLC22A17 was significantly higher in cases with histological grade 3 (P < 0.0005), advanced FIGO stage (P = 0.002), deep myometrial invasion (P = 0.029), positive lymph-vascular space invasion (P = 0.029), positive intraperitoneal cytology (P = 0.020) and adnexal metastasis (P = 0.029). The expression of SLC22A17 and LCN2 was positively correlated with a significant difference (P = 0.002), and the patients who overexpressed both SLC22A17 and LCN2 showed poorer survival than those without the expression of SLC22A17 or LCN2 (P = 0.002). Moreover, the overexpression of both SLC22A17 and LCN2 was indicated to be an independent prognostic factor by multivariable analysis.ConclusionsThese results suggested that SLC22A17, in cooperation with LCN2, to be involved in the acquisition of aggressive behavior among endometrial carcinoma cells.


► SLC22A17 is the cell surface receptor of LCN2.
► SLC22A17 is up-regulated in some of endometrial carcinomas (EC).
► Overexpression of SLC22A17 is associated in increasing malignant potential of EC.
► Overexpression of both SLC22A17 and LCN2 is the independent prognostic factor of EC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental and Molecular Pathology - Volume 91, Issue 2, October 2011, Pages 563–568
نویسندگان
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