کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2775299 | 1152320 | 2014 | 6 صفحه PDF | دانلود رایگان |
• VDR is expressed both in the cytoplasm and nucleus of skin cells in swine.
• Density of VDR+ nuclei was less in the skin of vitamin D-deficient swine.
• Intense CD86 expression correlated with vitamin D-sufficiency.
The immunomodulatory role of vitamin D in many diseases is well established. However, the relationship between vitamin D status and skin cancers is unclear. In this study, we examined the effect of vitamin D deficiency and sufficiency on VDR, NF-κB, and CD86 in the epidermis of Yucatan microswine tragi. All of these proteins have known roles in the pathogenesis of cutaneous malignancies such as melanoma and non-melanoma skin cancer. There was weaker and less discrete nuclear staining for VDR and weaker CD86 immunoreactivity with patchy membranous expression in the epidermis of vitamin D-deficient compared to vitamin D-sufficient swine. There was no difference in the immunostaining for NF-κB. Since VDR and CD86 expression are decreased in the setting of melanoma and non-melanoma skin cancers, our findings suggest a potential role of vitamin D-deficiency in the progression of skin malignancies.
Journal: Experimental and Molecular Pathology - Volume 96, Issue 1, February 2014, Pages 42–47