کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2775450 1152327 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
DNA repair gene ERCC2 polymorphisms and risk of squamous cell carcinoma of the head and neck
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
DNA repair gene ERCC2 polymorphisms and risk of squamous cell carcinoma of the head and neck
چکیده انگلیسی

IntroductionGenetic aberrations of DNA repair enzymes are known to be common events and to be associated with different cancer entities. Aim of the following study was to analyze the genetic association of single nucleotide polymorphisms (SNP) of the DNA repair genes with the risk of squamous cell carcinoma of the head and neck (HNSCC).Materials and methodsGenetic variants ERCC2 Lys751Gln (rs13181), ERCC2 Asp312Asn (rs1799793), XRCC1 Arg194Trp (rs1799782); XRCC1 Gln399Arg (rs25487), XRCC1 Arg280His (rs25489) and XRCC3 Thr241Met (rs861539) were analyzed in a primary study group comprising 169 patients with histologically confirmed HNSCC and 463 healthy control subjects. Polymorphisms associated with HNSCC were furthermore analyzed in an independent replication study including 125 HNSCC.ResultsOnly the ERCC2 751 Gln/Gln genotype was associated with HNSCC in the primary study (p = 0.033) and in the replication study (p = 0.023), resulting in an overall odds ratio of 0.54 (95% confidence interval 0.35–0.92; p = 0.006).ConclusionCarriers of the homozygous ERCC2 751 Gln/Gln genotype may be at lower risk for HNSCC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental and Molecular Pathology - Volume 91, Issue 1, August 2011, Pages 331–334
نویسندگان
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