Hypoxia, hypoxia-inducible factor-1α and vascular endothelial growth factor in a murine model of Schistosoma mansoni infection

► Schistosoma mansoni, produces a hypoxic tissue microenvironment. ► Schistosoma mansoni infection induces HIF-1α and VEGF expression. ► Schistosoma mansoni infected murine liver, intestine and spleen showed pimonidazole binding and HIF-1α and VEGF expression. ► Schistosoma mansoni infection generates hypoxia and HIF-1α and VEGF expression. ► A hypoxia-dependent HIF-1α activation in Schistosoma mansoni infected mice.