کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2777469 1568011 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chronic pancreatitis and the composition of plasma phosphatidylcholine fatty acids
ترجمه فارسی عنوان
پانکراتیت مزمن و ترکیب اسید فسفاتیدیل کولین پلاسما
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
چکیده انگلیسی


• We studied the fatty acid profile of plasma phosphatidylcholines in the group of patients with chronic pancreatitis (CP).
• FA pattern in CP results from low dietary fat intake and changed metabolism due to alteration of desaturase activities.
• Changes in FA profile implicated disturbed FA metabolism in CP and advocate proper nutritional support including n-3 PUFA.

Chronic pancreatitis (CP) is an irreversible inflammatory disorder characterized by the destruction of both exocrine and endocrine tissue. There is growing evidence that dysregulation of fatty acid (FA) metabolism is connected with many diseases; however, there are few data concerning FA composition in CP. Therefore, we analyzed FA profiles in plasma phosphatidylcholines in 96 patients with CP and in 108 control subjects (CON).The patients with CP had, in comparison with CON, increased sum of monounsaturated FA (ΣMUFA) and decreased content of polyunsaturated FA (PUFA) in both n-6 and n-3 families. Moreover, CP patients had increased indexes for delta-9, delta-6 desaturases, and fall in activity of delta-5 desaturase. Increased ratio of 16:1n-7/18:2n-6 (marker of essential n-6 FA deficiency), was more prevalent among CP patients.These changes implicated decreased fat intake, including n-3 as well as n-6 PUFA, and intrinsic changes in FA metabolism due to the alteration of delta desaturase activities.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Volume 108, May 2016, Pages 38–44
نویسندگان
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