کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2777630 1152744 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fish oil improves motor function, limits blood–brain barrier disruption, and reduces Mmp9 gene expression in a rat model of juvenile traumatic brain injury
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
Fish oil improves motor function, limits blood–brain barrier disruption, and reduces Mmp9 gene expression in a rat model of juvenile traumatic brain injury
چکیده انگلیسی

The effects of an oral fish oil treatment regimen on sensorimotor, blood–brain barrier, and biochemical outcomes of traumatic brain injury (TBI) were investigated in a juvenile rat model. Seventeen-day old Long-Evans rats were given a 15 mL/kg fish oil (2.01 g/kg EPA, 1.34 g/kg DHA) or soybean oil dose via oral gavage 30 min prior to being subjected to a controlled cortical impact injury or sham surgery, followed by daily doses for seven days. Fish oil treatment resulted in less severe hindlimb deficits after TBI as assessed with the beam walk test, decreased cerebral IgG infiltration, and decreased TBI-induced expression of the Mmp9 gene one day after injury. These results indicate that fish oil improved functional outcome after TBI resulting, at least in part from decreased disruption of the blood–brain barrier through a mechanism that includes attenuation of TBI-induced expression of Mmp9.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Volume 90, Issue 1, January 2014, Pages 5–11
نویسندگان
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