کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2777825 | 1152765 | 2011 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Brain protection by rapeseed oil in magnesium-deficient mice Brain protection by rapeseed oil in magnesium-deficient mice](/preview/png/2777825.png)
Diets given for 30 days with various mono-(MUFA) and poly-(PUFA) unsaturated fatty acid contents were evaluated for brain protection in magnesium-deficient mice: a commercial and three synthetic diets (n-6PUFA, n-3PUFA and MUFA-based chows enriched with 5% corn/sunflower oils 1:3, with 5% rapeseed oil and with 5% high oleic acid sunflower oil/sunflower oil 7:3, respectively). Unlike magnesium deprivation, they induced significant differences in brain and erythrocyte membrane phospholipid fatty acid compositions. n-3PUFA but not other diets protected magnesium-deficient mice against hyperactivity and moderately towards maximal electroshock- and NMDA-induced seizures. This diet also inhibited audiogenic seizures by 50%, preventing animal deaths. Because, like n-6PUFA diet, matched control MUFA diet failed to induce brain protections, alpha-linolenate (ALA) rather than reduced n-6 PUFA diet content is concluded to cause n-3PUFA neuroprotection. Present in vivo data also corroborate literature in vitro inhibition of T type calcium channels by n-3 PUFA, adding basis to ALA supplementation in human anti-epileptic/neuroprotective strategies.
► Magnesium-deficient diet in mice predisposes brain to hyperexcitability and to audiogenic seizures.
► n-3 and n-6 PUFA contents of magnesium-deficient diet differently affect brain excitability.
► Diet n-3 PUFA α-linolenate protects against magnesium deficiency induced brain toxicity.
► Protection by diet α-linolenate (ALA) is associated with rise in brain ALA and EPA (C20:5, n-3) levels.
► Features of α-linolenate protection in audiogenic seizures suggest entremise of T type Ca++ channels.
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids - Volume 85, Issue 2, August 2011, Pages 53–60