کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2777901 1568035 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dietary n-3 polyunsaturated fatty acid deprivation together with early maternal separation increases anxiety and vulnerability to stress in adult rats
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
Dietary n-3 polyunsaturated fatty acid deprivation together with early maternal separation increases anxiety and vulnerability to stress in adult rats
چکیده انگلیسی

Low concentrations of n-3 polyunsaturated fatty acid (PUFA) and chronic stress are implicated in susceptibility to mood disorders. We have investigated the combined effects of chronic n-3 PUFA dietary deficiency and early maternal separation (MS) stress on the reactivity to stressful situations of rats as adults.Pups fed a control or an n-3 PUFA deficient diet were daily separated for two weeks before weaning They were all tested at 3 month-old to determine their anxiety, and their ability to learn two aversive tasks differing in the control they could exert on the situation: auditory fear conditioning and brightness avoidance discrimination.Neither the n-3 PUFA-deficient diet nor MS alone significantly affected behavior. But n-3 PUFA-deficient rats that had been separated were more anxious and fearful in inescapable situations, while their ability to cope with an aversive avoidance task remained unaffected.These results support the notion that PUFA-unbalanced diet, together with stress, may be a determinant risk factor in emotional disorders.


► Lack of n-3PUFA in rats predisposes to heightened behavioral stress-induced reactions.
► n-3PUFA deficiency and maternal separation increases fear in stressful situation.
► Avoidance task is not affected by n-3PUFA deficiency or maternal separation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids - Volume 85, Issues 3–4, September–October 2011, Pages 129–136
نویسندگان
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