کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2785836 1645505 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neuronal death after perinatal cerebral hypoxia-ischemia: Focus on autophagy—mediated cell death
ترجمه فارسی عنوان
مرگ عصبی پس از ایسکمی هیپوکسی مغزی پریناتال: تمرکز بر اتوفایگی، مرگ سلولی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
چکیده انگلیسی

Neonatal hypoxic-ischemic encephalopathy is a critical cerebral event occurring around birth with high mortality and neurological morbidity associated with long-term invalidating sequelae. In view of the great clinical importance of this condition and the lack of very efficacious neuroprotective strategies, it is urgent to better understand the different cell death mechanisms involved with the ultimate aim of developing new therapeutic approaches. The morphological features of three different cell death types can be observed in models of perinatal cerebral hypoxia-ischemia: necrotic, apoptotic and autophagic cell death. They may be combined in the same dying neuron. In the present review, we discuss the different cell death mechanisms involved in neonatal cerebral hypoxia-ischemia with a special focus on how autophagy may be involved in neuronal death, based: (1) on experimental models of perinatal hypoxia-ischemia and stroke, and (2) on the brains of human neonates who suffered from neonatal hypoxia-ischemia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Developmental Neuroscience - Volume 45, October 2015, Pages 75–85
نویسندگان
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