Keywords: AIF، عامل القاء آپوپتوز; ACTH, Adrenocorticotropic hormone; AIF, Apoptosis inducing factor; AKI, Acute kidney injury; BMSC, Bone marrow derived stem cells; CIN, Contrast-induced nephropathy; COMP-Ang1, Cartilage oligomeric matrix protein-angiopoietin-1; CysLT1R, Cysteinyl leukotr
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Keywords: AIF، عامل القاء آپوپتوز; ABC, ATP-binding cassette; ABCG2, ATP-binding cassette sub-family G member 2; AIF, apoptosis inducing factor; ALA, aminolevulinic acid; BCC, basal cell carcinoma; BCG, Bacillus Calmette-Guerin; CG, cholangiocarcinoma; CTL, cytotoxic T-lymphocyte; DR4/DR5,
Keywords: AIF، عامل القاء آپوپتوز; AIF, apoptosis inducing factor; Atg, autophagy related genes; HI, hypoxia-ischemia; HIE, hypoxic-ischemic encephalopathy; Ka, kainate; LC-3, microtubule-associated light chain 3 protein; LAMP1, light chain associated membrane protein 1; NMDA, N-methyl-d-a
Deoxynivalenol induces apoptosis in PC12 cells via the mitochondrial pathway
Keywords: AIF، عامل القاء آپوپتوز; DON, deoxynivalenol; Cyt C, cytochrome C; AIF, apoptosis inducing factor; DMEM, dulbecco’s modified eagle’s medium; FBS, fetal bovine serum; CCK-8, cell counting kit-8; OD, optical density; BSA, bovine serum albumin; PI, propidium iodide; LDH, lactate deh
Role of nicotinamide (vitamin B3) in acetaminophen-induced changes in rat liver: Nicotinamide effect in acetaminophen-damged liver
Keywords: AIF، عامل القاء آپوپتوز; 2PY, N-methyl-2-pyridone-5-carboxamide; 4PY, N-methyl-4-pyridone-5-carboxamide; AIF, apoptosis inducing factor; ALP, alkaline phosphatase; ALT, alanine transaminase; APAP, acetaminophen; AST, aspartate aminotransferase; BUN, blood urea nitrogen; GPx, glut
Mitochondrial translocator protein (TSPO): From physiology to cardioprotection
Keywords: AIF، عامل القاء آپوپتوز; AIF, apoptosis inducing factor; ANT, adenine nucleotide translocase; Bax, Bcl-2-associated X protein; Bcl-2, B-cell lymphoma 2; IMAC, inner membrane anion channel; mPTP, mitochondrial permeability transition pore; PBR, peripheral benzodiazepine receptors;
Neuroprotective action of resveratrol
Keywords: AIF، عامل القاء آپوپتوز; Aβ, beta-amyloid; AD, Alzheimer's disease; AIF, Apoptosis Inducing Factor; AMPK, AMP-activated protein kinase; AP-1, activator protein-1; BBB, blood-brain barrier; COX, cyclooxygenase; APP, amyloid precursor protein; ERK1/2, extracellular signal-regulated
Suppression in PHLPP2 induction by morin promotes Nrf2-regulated cellular defenses against oxidative injury to primary rat hepatocytes
Keywords: AIF، عامل القاء آپوپتوز; AIF, apoptosis inducing factor; APAP, acetaminophen; ARE, antioxidant redox element; DCFH-DA, 2′,7′-dichlorofluorescein diacetate; DHE, dihydroethidium; ELISA, enzyme-linked immunosorbent assay; FITC, fluorescein isothiocyanate; GAPDH, glyceraldehyde phos
Inhibition of autophagy by 3-MA potentiates purvalanol-induced apoptosis in Bax deficient HCT 116 colon cancer cells
Keywords: AIF، عامل القاء آپوپتوز; AIF, apoptosis inducing factor; ABTS, 2, 2′-Azino-di-3-ethylbenzthiazoline sulfonate (6) diammonium salt; AO, acridine orange; BH, Bcl-2 homology; CDK, cyclindependent kinase; DiOC6, 3,3′-dihexyloxacarbocyanine iodide; DMSO, dimethylsulfoxide; HRP, horser
Naringenin accords hepatoprotection from streptozotocin induced diabetes in vivo by modulating mitochondrial dysfunction and apoptotic signaling cascade
Keywords: AIF، عامل القاء آپوپتوز; ΨΔm, mitochondrial membrane potential; AGE, advanced glycated end products; AIF, apoptosis inducing factor; Bax, bcl-2 associated X; Bcl-2, b-cell Lymhoma-2; CAT, catalase; cDNA, complementary; DNA,COX-II, cyclo-oxygenase-II; DCF, dichlorofluorescein; DCF
Human-Gyrovirus-Apoptin Triggers Mitochondrial Death Pathway—Nur77 is Required for Apoptosis Triggering
Keywords: AIF، عامل القاء آپوپتوز; 7AAD, 7-amino-actinomycin D; AIF, Apoptosis inducing factor; BCL-XL, B-cell lymphoma extra-large; CAV-Apoptin, Chicken anemia virus apoptin; cyt c, cytochrome c; DISC, Death-inducing signal complex; FADD, Fas-associated death domain; HGV-Apoptin, Human gy
The protective role of yeast Cathepsin D in acetic acid-induced apoptosis depends on ANT (Aac2p) but not on the voltage-dependent channel (Por1p)
Keywords: AIF، عامل القاء آپوپتوز; AAC, ADP/ATP carrier; AIF, apoptosis inducing factor; CatD, Cathepsin D; DHE, dihydroethidium; DPM-Pep4p, double point mutant Pep4p; GFP, green fluorescent protein; LMP, lysosomal membrane permeabilizatiom; MOMP, mitochondrial outer membrane permeabilizat
Multiple interacting cell death mechanisms in the mediation of excitotoxicity and ischemic brain damage: A challenge for neuroprotection
Keywords: AIF، عامل القاء آپوپتوز; AIF, apoptosis inducing factor; Ambra1, activating molecule in beclin1-regulated autophagy; Apaf-1, adapter protein apoptotic protease-activating factor-1; ASIC, acid-sensing ion channel; atg, autophagic related genes; Bad, Bcl-2-associated death promoter
Hsp70 promotes chemoresistance by blocking Bax mitochondrial translocation in ovarian cancer cells
Keywords: AIF، عامل القاء آپوپتوز; Smac/DIABLO, second mitochondria-derived activator of caspases/direct IAP binding protein with low pI; HtrA2, high temperature requirement A; AIF, apoptosis inducing factor; IAP, inhibitor of apoptosis protein; DMSO, dimethyl sulfoxide; BIR, baculovirus I
N1-(quinolin-2-ylmethyl)butane-1,4-diamine, a polyamine analogue, attenuated injury in in vitro and in vivo models of cerebral ischemia
Keywords: AIF، عامل القاء آپوپتوز; AIF, apoptosis inducing factor; AO, acridine orange; CNS, central nerver system; CNQX, 6-cyano-7-nitroquinoxaline-2,3-dione; DCF-DA, 2′,7′-dichlorofluorescein diacetate; DMEM, Dulbecco's modified eagle's medium; EB, ethidium bromide; Glu, glumate; GSH-px,
The protective effect of Alpha lipoic acid on Schwann cells exposed to constant or intermittent high glucose
Keywords: AIF، عامل القاء آپوپتوز; AIF, apoptosis inducing factor; ALA, Alpha lipoic acid; Apaf-1, apoptotic protease-activating factor-1; cyto c, cytochrome c; DPN, diabetic peripheral neuropathy; 8-OHdG, 8-hydroxy-2-deoxy Guanosine; HG, high glucose; IHG, intermitient high glucose; SDS-P
Physical exercise as a possible strategy for brain protection: Evidence from mitochondrial-mediated mechanisms
Keywords: AIF، عامل القاء آپوپتوز; AIF, apoptosis inducing factor; ATP, adenosine triphosphate; AD, Alzheimer disease; BDNF, brain-derived neurotrophic factor; Ca2+, calcium; CAT, catalase; Cu/Zn-SOD, copper/zinc superoxide dismutase; Drp1, dynamin-related protein 1; ETC, electron transpor
Combined inhibition of cell death induced by apoptosis inducing factor and caspases provides additive neuroprotection in experimental traumatic brain injury
Keywords: AIF، عامل القاء آپوپتوز; AIF, apoptosis inducing factor; BAF, boc-aspartyl(OMe)-fluoromethylketone; CCI, controlled cortical impact; CypA, Cyclophilin A; Hq, harlequin; ICV, intracerebroventricular; PCD, programmed cell death; TBI, traumatic brain injuryTraumatic brain injury; Ap
Subcellular targets of cisplatin cytotoxicity: An integrated view
Keywords: AIF، عامل القاء آپوپتوز; AIF, Apoptosis inducing factor; ATP7A and ATP7B, Copper P-type adenosine triphosphate transporters 7A and 7B; C, Caspase; CAT, Catalase; CL, Cardiolipin; c-Abl, Abelson murine leukemia viral oncogene homologue; CHOP, CCAAT-binding homologous protein; Cyt,
A novel Rieske-type protein derived from an apoptosis-inducing factor-like (AIFL) transcript with a retained intron 4 induces change in mitochondrial morphology and growth arrest
Keywords: AIF، عامل القاء آپوپتوز; AIF, apoptosis inducing factor; AMID, apoptosis-inducing factor-homologous mitochondrion-associated inducer of death; AIFL, apoptosis inducing factor-like; Pyr_redox, pyridine nucleotide-disulfide oxidoreductase; PRG3, p53-responsive gene 3AIFL; Rieske do
Alzheimer's disease: Effects of β-amyloid on mitochondria
Keywords: AIF، عامل القاء آپوپتوز; 4-HNE, 4-Hydroxy-2-nonenal; ABAD, β-amyloid binding alcohol dehydrogenase; AD, Alzheimer's disease; APP, Amyloid Precursor Protein; apoE, apolipoprotein E; LRP1, LDL receptor-related protein 1; AIF, apoptosis inducing factor; Drp-1, dynamin-related protei
Alpha-phenyl-N-tert-butylnitrone prevents oxidative stress in a haloperidol-induced animal model of tardive dyskinesia: Investigating the behavioural and biochemical changes
Keywords: AIF، عامل القاء آپوپتوز; PBN, Alpha-phenyl-N-tert-butylnitrone; AIF, Apoptosis inducing factor; DA, Dopamine; GSH, Glutathione; HP, Haloperidol; ROS, Reactive oxygen species; SOD, Superoxide dismutase; TD, Tardive dyskinesia; VCM, Vacuous chewing movementAlpha-phenyl-N-tert-butyl
Abrogation of nimesulide induced oxidative stress and mitochondria mediated apoptosis by Fumaria parviflora Lam. extract
Keywords: AIF، عامل القاء آپوپتوز; Ψm, mitochondrial membrane potential; ADR, adverse drug reaction; AIF, apoptosis inducing factor; ApoAF-1, apoptosis activating factor-1; BHA, butylated hydroxyanisole; BHT, butylated hydroxytoluene; CAD, caspases activated DNase; CMF, chloromethylfluores
Methadone induces CAD degradation and AIF-mediated necrotic-like cell death in neuroblastoma cells
Keywords: AIF، عامل القاء آپوپتوز; AIF, apoptosis inducing factor; CAD, caspase activated DNase; CsA, cyclosporin A; HMW, high molecular weight; ICAD, inhibitor of caspase activated DNase; LMWF, low molecular weight fragments; MEF, mouse embryonic fibroblast; Meth, methadone; MOMP, mitocho
Modulation of Bax/Bcl-2 and caspases by probiotics during acetaminophen induced apoptosis in primary hepatocytes
Keywords: AIF، عامل القاء آپوپتوز; AIF, apoptosis inducing factor; ATP, adenosine triphosphate; APAP, acetaminophen; cyt c, cytochrome c; DCF, dichlorofluorescein; DCFH–DA, dichlorofluorescein–diacetate; EDTA, ethylenediamine tetraacetic acid; EGTA, ethylene glycol tetra acetic acid; ElSN,
Dietary phytochemicals induce p53- and caspase-independent cell death in human neuroblastoma cells
Keywords: AIF، عامل القاء آپوپتوز; 7-AAD, 7-aminoactinomycin D; AIF, apoptosis inducing factor; IκB, inhibitor of NFκB; LDH, lactate dehydrogenase; NB, neuroblastoma; NFκB, nuclear factor-κB; N-type, neuroblastic cells; PFT-α, pifithrin-α; S-type, stromal (Schwannian) cellsAyurveda; Akt; P
Thioredoxin reductase 1 knockdown enhances selenazolidine cytotoxicity in human lung cancer cells via mitochondrial dysfunction
Keywords: AIF، عامل القاء آپوپتوز; AIF, apoptosis inducing factor; ASK1, apoptosis signaling kinase 1; BSO, L-buthionine-(S,R)-sulfoximine; BSCA, 2-butylselenazolidine-4(R)-carboxylic acid; CDDP, cis-platinum(II) diammine dichloride; ChSCA, 2-cyclohexylselenazolidine-4(R)-carboxylic acid;
A novel parthenin analog exhibits anti-cancer activity: Activation of apoptotic signaling events through robust NO formation in human leukemia HL-60 cells
Keywords: AIF، عامل القاء آپوپتوز; AIF, apoptosis inducing factor; AML, acute myeloid leukemia; DR4, death receptor 4; DR5, death receptor 5; DRP-1, dynamin related protein-1; GSH, glutathione reduced; iNOS, inducible nitric oxide synthase; NAC, N-acetyl-l-cysteine; NF-κB, nuclear factor-k
Therapeutic applications of compounds in the Magnolia family
Keywords: AIF، عامل القاء آپوپتوز; Magnolia; Magnolol; Obovatol; Honokiol; 4-O-methylhonokiol; Cancer; Nerve; Alzheimer disease; Cardiovascular disease; Inflammatory diseaseACH, acetylcholine; ACHE, acetylcholinesterase; AIF, apoptosis inducing factor; ATP, adenosine triphosphate; Bax, Bcl
Photodynamic properties of ZnTPPS4, ClAlPcS2 and ALA in human melanoma G361 cells
Keywords: AIF، عامل القاء آپوپتوز; 1O2, singlet oxygen; AIF, apoptosis inducing factor; ALA, 5-aminolevulinic acid; AlPc, aluminium phtalocyanine; ClAlPcS2, chloraluminium phtalocyanine disulfonate; CM-H2DCFDA, 5-(and-6)-chloromethyl-2′,7′-dichlorodihydrofluorescein diacetate; DMEM, Dullbe
Oxidized low-density lipoprotein (oxLDL) induces cell death in neuroblastoma and survival autophagy in schwannoma cells
Keywords: AIF، عامل القاء آپوپتوز; AIF, apoptosis inducing factor; DRG, dorsal root ganglion, LC3, microtubule-associated protein light chain 3; LDL, low-density lipoprotein; LOX-1, lectin-like oxidized low-density lipoprotein receptor-1; TLR4, toll-like receptor-4OxLDL; Cell death; Autoph
Multistep and multitask Bax activation
Keywords: AIF، عامل القاء آپوپتوز; AIF, apoptosis inducing factor; ANT, adenine nucleotide translocator; AP-1, activator protein-1; Bax, Bcl-2 homolog X; Bcl-2, B-cell lymphoma-2; BH, Bcl-2-homology; DISC, death inducing signaling complex; ER, endoplasmic reticulum; IAP, inhibitor of apopt
Temporal and Spatial Changes in Collateral Formation and Function During Chronic Myocardial Ischemia
Keywords: AIF، عامل القاء آپوپتوز; AAR, area at risk (ischemic myocardial territory); AIF, apoptosis inducing factor; eNOS, endothelial nitric oxide synthase; ERK, extracellular signal regulated kinase; ET-1, endothelin-1; HSP, heat shock protein; ILM, isotope-labeled microspheres; LCx, le
UV radiation in marine ectotherms: Molecular effects and responses
Keywords: AIF، عامل القاء آپوپتوز; AIF, apoptosis inducing factor; CAT, catalase; CPD, cyclobutane pyrimidine dimers; DOC, dissolved organic carbon; DOM, dissolved organic matter; GPx (=GSH-Px), glutathione peroxidase; Hsp, heat shock protein; LPO, lipid peroxidase; MAAs, mycosporine-like
Transcriptional and post-transcriptional regulation of mitochondrial biogenesis in skeletal muscle: Effects of exercise and aging
Keywords: AIF، عامل القاء آپوپتوز; Δψm, mitochondrial membrane potential; AAC, ADP/ATP carrier; AIF, apoptosis inducing factor; AKT, protein kinase B; AMPK, AMP-activated protein kinase; ATF2, activating transcription factor 2; AUF1, ARE-associated factor; Ca2+, calcium; CaMKIV, calcium/ca
Mitochondria, oxidative metabolism and cell death in stroke
Keywords: AIF، عامل القاء آپوپتوز; AIF, apoptosis inducing factor; AKAP121, A-kinase anchor protein 121; APAF-1, apoptotic protease activating factor 1; IAPs, inhibitor-of-apoptosis proteins; JNK, c-Jun N-terminal kinase; MCA, middle cerebral artery; Omi/HtrA2, Omi stress-regulated endopro
Involvement of mitochondria mediated pathways in hepatoprotection conferred by Fumaria parviflora Lam. extract against nimesulide induced apoptosis in vitro
Keywords: AIF، عامل القاء آپوپتوز; ΔΨm, mitochondrial membrane potential; AIF, apoptosis inducing factor; ApoAF-1, apoptosis activating factor-1; ATP, adenosine triphosphate; BHA, butylated hydroxyanisole; BHT, butylated hydroxytoluene; CAD, caspases-activated DNase, CMF, chloromethylfluor
Models of accelerated sarcopenia: Critical pieces for solving the puzzle of age-related muscle atrophy
Keywords: AIF، عامل القاء آپوپتوز; 4EBP1, eukaryotic translation initiation factor 4E binding protein 1; atrogin1/MAFbx, muscle atrophy F box; AIF, apoptosis inducing factor; CI, caloric insufficiency; CKD, chronic kidney disease; CNF, ciliary neurotrophic factor; COPD, chronic obstructive
Multifarious molecular signaling cascades of cardiac hypertrophy: Can the muddy waters be cleared?
Keywords: AIF، عامل القاء آپوپتوز; AC, Adenylyl cyclase; AIF, Apoptosis inducing factor; Akt, Protein kinase B; ANP, Atrial natriuretic peptide; APAF, Apoptotic peptidase activating factor 1; AR, Adrenergic receptor; AT1R, Angiotensin-II-AT1 receptor; ATP, Adenosine triphosphate; B2, Brady
Mitochondrial gateways to cancer
Keywords: AIF، عامل القاء آپوپتوز; ACL, ATP citrate lyase; AIF, apoptosis inducing factor; AML, acute myeloid leukemia; ANT, adenine nucleotide translocase; BH, Bcl-2 homology domain; CRT, calreticulin; CypD, cyclophilin D; Cyt c, cytochrome c; Δψm, mitochondrial transmembrane potential; D
Cadmium-induced apoptosis is mediated by the translocation of AIF to the nucleus in rat testes
Keywords: AIF، عامل القاء آپوپتوز; AA, ascorbic acids; AIF, apoptosis inducing factor; Cd, cadmium; BSA, bovine serum albumin; MDA, malondialdehyde; PARP-1, poly ADP-ribose polymerase-1; PBS, potassium buffered saline; ROS, reactive oxygen species; S.D., standard deviation; SDS–PAGE, sodiu
Oxidative stress induction by T-2 toxin causes DNA damage and triggers apoptosis via caspase pathway in human cervical cancer cells
Keywords: AIF، عامل القاء آپوپتوز; AIF, apoptosis inducing factor; CHAPS, 3[(3-cholamidopropyl) dimethlylammonio]-1-propanesulfate; CVDE, crystal violet dye exclusion; DCF-DA, 2,7-dichlorofluorescein diacetate; DTT, dithiothreitol; GSH, glutathione; LDH, lactate dehydrogenase; OPT, orthoph
Glycyrrhizic acid modulates t-BHP induced apoptosis in primary rat hepatocytes
Keywords: AIF، عامل القاء آپوپتوز; ΔΨm, mitochondrial membrane potential; AIF, apoptosis inducing factor; APAF-1, apoptosis protease activating factor-1; CAD, caspases-activated DNase; CMF-DA, 5′-chloromethylfluorescein diacetate; DCF, dichlorofluorescein; DCFH2, dichlorodihydrofluorescein
The maintenance of hippocampal pyramidal neuron populations is dependent on the modulation of specific cell cycle regulators by thyroid hormones
Keywords: AIF، عامل القاء آپوپتوز; 5′D, 5′-deiodination; AIF, apoptosis inducing factor; CD1, cycline D1; CNS, central nervous system; D2, deiodinase type 2; DTT, dithiothreitol; hD2, hippocampal deiodinase type 2; MMI, methimazole; PCNA, proliferating cell nuclear antigen; PTU, 6-n-propyl
Role of BNIP3 in TNF-induced cell death — TNF upregulates BNIP3 expression
Keywords: AIF، عامل القاء آپوپتوز; TNF, tumor necrosis factor alpha; AIF, apoptosis inducing factor; Endo-G, Endonuclease G; tBid, truncated bid; BNIP3, Bcl2/E1B 19kD interacting protein; TM, trans-membrane; PTP, permeability transition pore; HIF-1α, hypoxia inducing factor-alpha-1; NO, ni
Cytotoxic effects of oxysterols associated with human diseases: Induction of cell death (apoptosis and/or oncosis), oxidative and inflammatory activities, and phospholipidosis
Keywords: AIF، عامل القاء آپوپتوز; AIF, apoptosis inducing factor; Akt/PKB, protein kinase B; AP-1, activator protein 1; ABCA1, ATP-binding cassette A1; COX, cyclooxygenase; Endo-G, endonuclease-G; ICAD, inhibitor of caspase-activated DNase; ICAM-1, intercellular adhesion molecule-1; IL, i
Cell death and proliferation in acute slices and organotypic cultures of mammalian CNS
Keywords: AIF، عامل القاء آپوپتوز; ACSF, artificial cerebro-spinal fluid; AD, Alzheimer disease; AIF, apoptosis inducing factor; ALS, amyotrophic lateral sclerosis; AMPA, α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid hydrate; Aβ, beta-amyloid peptide; BrdU, 5-bromodeoxyuridine; CGCs
PUMA inactivation protects against oxidative stress through p21/Bcl-XL inhibition of bax death
Keywords: AIF، عامل القاء آپوپتوز; AIF, Apoptosis inducing factor; PCNA, Proliferating cell nuclear antigen; PUMA, p53-upregulated modulator of apoptosis; ROS, Reactive oxygen species; SDS-PAGE, Sodium dodecyl sulfate–polyacrylamide gel electrophoresis; wt, Wild-typeFree radicals; Cell dea
microRNAs and death receptors
Keywords: AIF، عامل القاء آپوپتوز; AIF, Apoptosis Inducing Factor; DISC, death-inducing signaling complex; HMGA2, high mobility group A2; Ltn A, latrunculin A; RISC, RNA-induced silencing complex; tBid, truncated BidApoptosis; Fas; Let-7; Superclusters; TRAIL
Calcium-dependent proteolytic system and muscle dysfunctions: A possible role of calpains in sarcopenia
Keywords: AIF، عامل القاء آپوپتوز; Calpain; Muscle; Aging; Apoptosis; AtrophyER, endoplasmic reticulum; GA, golgi apparatus; MARCKS, myristoylated alanine rich C-kinase substrate; TNF, tumor necrosis factor; ROS, reactive oxygen species; AIF, apoptosis inducing factor; EndoG, endonuclease