کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2563062 1560942 2016 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Renoprotective approaches and strategies in acute kidney injury
ترجمه فارسی عنوان
روشها و استراتژی های محافظت کننده در برابر آسیب های حاد کلیه
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
چکیده انگلیسی

Acute kidney injury (AKI) is a major renal disease associated with high mortality rate and increasing prevalence. Decades of research have suggested numerous chemical and biological agents with beneficial effects in AKI. In addition, cell therapy and molecular targeting have been explored for reducing kidney tissue damage and promoting kidney repair or recovery from AKI. Mechanistically, these approaches may mitigate oxidative stress, inflammation, cell death, and mitochondrial and other organellar damage, or activate cytoprotective mechanisms such as autophagy and pro-survival factors. However, none of these findings has been successfully translated into clinical treatment of AKI. In this review, we analyze these findings and propose experimental strategies for the identification of renoprotective agents or methods with clinical potential. Moreover, we propose the consideration of combination therapy by targeting multiple targets in AKI.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 163, July 2016, Pages 58–73
نویسندگان
, , , , , , , , ,