کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2786484 1568418 2011 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Long-lasting effects of perinatal asphyxia on exploration, memory and incentive downshift
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Long-lasting effects of perinatal asphyxia on exploration, memory and incentive downshift
چکیده انگلیسی

Perinatal asphyxia remains as one of the most important causes of death and disability in children, without an effective treatment. Moreover, little is known about the long-lasting behavioral consequences of asphyxia at birth. Therefore, the main aim of the present study was to investigate the motor, emotional and cognitive functions of adult asphyctic rats. Experimental subjects consisted of rats born vaginally (CTL), by cesarean section (C+), or by cesarean section following 19 min of asphyxia (PA). At three months of age, animals were examined in a behavioral test battery including elevated plus maze, open field, Morris water maze, and an incentive downshift procedure. Results indicated that groups did not differ in anxiety-related behaviors, although a large variability was observed in the asphyctic group and therefore, the results are not completely conclusive. In addition, PA and C+ rats showed a deficit in exploration of new environments, but to a much lesser extent in the latter group. Spatial reference and working memory impairments were also found in PA rats. Finally, when animals were downshifted from a 32% to a 4% sucrose solution, an attenuated suppression of consummatory behavior was observed in PA rats. These results confirmed and extended those reported previously about the behavioral alterations associated with acute asphyxia around birth.


► Adult male rats, which had undergone acute birth asphyxia, show deficits in exploration.
► Perinatal asphyxia is associated with reference and working memory impairments.
► Asphyctic rats display attenuated behavioral response to an incentive downshift.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Developmental Neuroscience - Volume 29, Issue 6, October 2011, Pages 609–619
نویسندگان
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