P2Y2 receptor expression is altered in rats after spinal cord injury

▶ Spinal cord injury induces P2Y2 mRNA expression. ▶ Trauma to the spinal cord upregulates the un-glycosylated form of the P2Y2 receptor. ▶ Contusion to the cord downregulates the glycosylated form of the P2Y2 receptor. ▶ P2Y2 receptor is expressed in neurons and glial cells of the injured spinal cord. ▶ The spatio-temporal pattern of P2Y2 gene expression after injury suggests a role in the pathophysiology response generated after trauma.