کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2792338 1568670 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effect of osteoporosis treatments on fatigue properties of cortical bone tissue
ترجمه فارسی عنوان
تأثیر درمان پوکی استخوان بر ویژگی های خستگی بافت استخوانی کورتکس
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی


• Cortical bone beams from sheep with osteoporosis treatments were tested in fatigue.
• Alendronate lowered fatigue life while zoledronate did not alter fatigue life.
• PTH treatment increased fatigue life of cortical bone tissue.
• Effect on fatigue life differs by type of osteoporosis treatment in cortical bone.

Bisphosphonates are commonly prescribed for treatment of osteoporosis. Long-term use of bisphosphonates has been correlated to atypical femoral fractures (AFFs). AFFs arise from fatigue damage to bone tissue that cannot be repaired due to pharmacologic treatments. Despite fatigue being the primary damage mechanism of AFFs, the effects of osteoporosis treatments on fatigue properties of cortical bone are unknown. To examine if fatigue-life differences occur in bone tissue after different pharmacologic treatments for osteoporosis, we tested bone tissue from the femurs of sheep given a metabolic acidosis diet to induce osteoporosis, followed by treatment with a selective estrogen reception modulator (raloxifene), a bisphosphonate (alendronate or zoledronate), or parathyroid hormone (teriparatide, PTH). Beams of cortical bone tissue were created and tested in four-point bending fatigue to failure. Tissue treated with alendronate had reduced fatigue life and less modulus loss at failure compared with other treatments, while tissue treated with PTH had a prolonged fatigue life. No loss of fatigue life occurred with zoledronate treatment despite its greater binding affinity and potency compared with alendronate. Tissue mineralization measured by microCT did not explain the differences seen in fatigue behavior. Increased fatigue life with PTH suggests that current treatment methods for AFF could have beneficial effects for restoring fatigue life. These results indicate that fatigue life differs with each type of osteoporosis treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone Reports - Volume 2, June 2015, Pages 8–13
نویسندگان
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