کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2794000 1155242 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of BAFF in the progression of rheumatoid arthritis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
The role of BAFF in the progression of rheumatoid arthritis
چکیده انگلیسی


• BAFF is increased in autoimmune diseases and is correlated with disease activity.
• Expression of BAFF and its receptors are disturbances in the RA progression.
• BAFF is involved in cell–cell interactions network in RA.
• Clinical trials showed BAFF antagonists were effective and safe.

Rheumatoid arthritis (RA) is a common autoimmune disease that is marked by a systemic inflammatory reaction and joint erosions. Elevated levels of B cell activating factor (BAFF) have been detected in the serum and synovial fluid of RA patients. Moreover, the levels of BAFF increase in cases of autoimmune disease and are correlated with the level of disease activity. As an innate cytokine mediator, BAFF affects the immune response of the synovial microenvironment. In this review, we consider recent observations of BAFF and its receptors in RA progression, as well as the effects of BAFF on the cell–cell interactions network. We also summarize the clinical development of BAFF antagonists for the treatment of RA.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 76, Issue 2, December 2015, Pages 537–544
نویسندگان
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