Enhancing CCL28 expression through the gene transfer to salivary glands for controlling cariogenic microbe

► A recombinant eukaryotic plasmid expressing CCL28 was constructed. ► The CCL28 protein got could strongly inhibit S. mutans in biofilm in vitro. ► Introducing the plasmid to rat parotid glands enhanced CCL28 output. ► Dental plaque from the gene transferred rats harbored much less S. mutans.