The role of cytokines and chemokines in Histoplasma capsulatum infection

Histoplasma capsulatum is a prevalent fungal pathogen in the United States, infecting approximately 500,000 individuals each year. Host protection requires an intact cell-mediated immune response. In this review, we will discuss how cytokines and chemokines influence protective immunity in H. capsulatum infection.

► The involvement of Th1 and Th17 cytokines in mediating a protective immune response to Histoplasma capsulatum.
► How cytokines such as IL-4 and IL-10 dampen protective immunity in H. capsulatum infection.
► The role of chemokines in the recruitment of immune cells and regulation of cytokine production.