Relationship of elevated osteoprotegerin with insulin resistance, CRP, and TNF-α levels in men with type 2 diabetes

Aim: Our objective of this study is to investigate the relationship between plasma osteoprotegerin (OPG) levels in type 2 diabetes and its relationship with the insulin resistance, HbA1c, CRP, and TNF-α levels. Methods: In a cross-sectional study, levels of OPG were determined in 50 subjects with type 2 diabetes and 59 control subjects without diabetes. The OPG levels between the groups were compared and their correlation with insulin resistance, glycemia and inflammatory markers CRP and TNF-α was determined. Results: OPG levels were elevated in subjects with diabetes (6.8 ± 0.27 pmol/l), compared to control subjects (5.7 ± 0.26 pmol/l). OPG levels significantly correlate with insulin, insulin resistance, CRP, and TNF-α. Conclusion: OPG levels are significantly correlated with insulin resistance and may reflect the proinflammatory state in type 2 diabetes.