کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2795432 | 1155325 | 2010 | 8 صفحه PDF | دانلود رایگان |
CKβ8/CCL23 is a CC chemokine and alternative splicing of the CKβ8 gene produces two mRNAs that encode CKβ8 and its isoform CKβ8-1. Chemokines play a critical role in leukocyte trafficking and development of inflammation and chemokines are also known to be involved in cell proliferation. To investigate participation of CKβ8 and CKβ8-1 in cell proliferation, we examined the effects of CKβ8 and CKβ8-1 in the cell cycle. Both CKβ8 and CKβ8-1 induced cell-cycle progression. We next investigated whether MAPKs are involved in CKβ8- and CKβ8-1-induced cell proliferation. CKβ8- and CKβ8-1-stimulated cells showed phosphorylation of ERK1/2 and an inhibitor study indicated that CKβ8- and CKβ8-1-induced activation of ERK1/2 is mediated by the Gi/Go protein, PLC, and PKCδ. CKβ8 and CKβ8-1 regulated expression of the cell cycle regulators cyclin D3 and cyclin B1, and the immediate early response gene products c-Myc and Egr-1. These results indicate that both CKβ8 and CKβ8-1 are involved in cell proliferation by modulating the cell cycle regulators.
Journal: Cytokine - Volume 50, Issue 1, April 2010, Pages 42–49