Nitric oxide rectifies acid-base disturbance and modifies thyroid hormone activity during net confinement of air-breathing fish (Anabas testudineus Bloch)

► Effects of NO donor SNP on physiologic processes were examined in fish. ► SNP lowers plasma T4 but promotes compensatory respiratory gas transport. ► SNP integrates the acid-base and osmotic balances in net-confined fish. ► Evidence is presented that NO can mitigate the magnitude of stress response.