کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2800417 1568924 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comparative aspects of kisspeptin gene regulation
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Comparative aspects of kisspeptin gene regulation
چکیده انگلیسی

Kisspeptin plays an important role in the onset of puberty through stimulation of gonadotropin-releasing hormone (GnRH), a master molecule of reproduction. Furthermore, the existence of multiple kisspeptins is evident in most vertebrate species. Therefore, elucidating the regulatory mechanisms of the kisspeptin genes is important to understand the functions of multiple kisspeptin forms in the brain. This review focuses on the comparative aspects of kisspeptin gene regulation with an emphasis on the role of environmental signals including gonadal steroids, photoperiods and metabolic signals. These environmental signals differently regulate the kisspeptin genes distinctively in each species. In addition, photoperiodic regulation of the kisspeptin genes alters during sexual maturational, suggesting interactions between the gonadal hormone pathway and the photoperiod pathway. Further studies of the regulatory mechanisms of kisspeptin genes especially in teleosts which possess multiple kisspeptin/kisspeptin receptor systems will help to understand the precise role of multiple kisspeptin forms in different species.


► A review of the regulation of the kisspeptin genes in comparative aspects.
► Promoters/enhancers for tissue-specific expression of kisspeptins are discussed.
► An emphasis on the roles of environmental signals in kisspeptin gene regulation.
► There are interactions between different signaling pathways.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: General and Comparative Endocrinology - Volume 181, 15 January 2013, Pages 197–202
نویسندگان
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