Prolactin and blood vessels: A comparative endocrinology perspective

The hormone prolactin (PRL), fundamental for lactation in mammals, is known to exert a wide diversity of actions in the various vertebrate groups. Blood vessels are surfacing as important PRL targets, contributing to these hormonal functions. PRL promotes the growth of new blood vessels (angiogenesis) and is proteolytically cleaved to vasoinhibins, a family of peptides (including 16-kDa PRL) with potent antiangiogenic and blood vessel regression effects. These opposing actions point to the regulation of the proteases responsible for PRL cleavage as an efficient way to balance blood vessel growth and involution. This review briefly summarizes the effects of PRL and vasoinhibins on blood vessels in mammals and discusses whether similar vascular actions could contribute to the effects of PRL on the development, growth, and reproduction of lower vertebrates. A comparative study in diverse species may lead to a better understanding of blood vessels as a driving force for the biological actions of PRL.

► Blood vessel proliferation and regression determine organ growth and involution.
► Prolactin is proangiogenic, but it acquires vasoinhibitory properties upon proteolytic cleavage.
► Opposing actions of PRL on blood vessels influence development and reproduction.
► A comparative approach could clarify the physiological effects of PRL on blood vessels.