کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2801943 | 1568933 | 2007 | 6 صفحه PDF | دانلود رایگان |

This study was performed in order to elucidate the role and importance of three mitogenic hormones [growth hormone (GH), insulin-like growth factor-I (IGF-1) and prolactin (PRL)] on heat shock protein 70 (HSP70) expression in a silver sea bream fibroblast cell line and a primary macrophage preparation. Fibroblasts and macrophages that were exposed to GH at concentrations of 1–1000 ng/ml did not exhibit modulated HSP70 expression, whereas GH at an exposure concentration of 10 ng/ml lowered HSP70 levels in macrophages. Upon exposure to IGF-1 it was found that HSP70 expression remained unchanged in fibroblasts but was significantly decreased in macrophages at exposure concentrations of 1–10 ng/ml. Finally, and using a preparation of ovine PRL it was found that HSP70 expression decreased in fibroblasts at exposure concentrations of 1–1000 ng/ml and also decreased in macrophages at exposure concentrations of 1–100 ng/ml.
Journal: General and Comparative Endocrinology - Volume 152, Issues 2–3, June–July 2007, Pages 183–188