کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2802367 1156200 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Melatonin and differential effect of l-thyroxine on immune system of Indian tropical bird Perdicula asiatica
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Melatonin and differential effect of l-thyroxine on immune system of Indian tropical bird Perdicula asiatica
چکیده انگلیسی

Interaction of thyroxine and melatonin on immune status was noted in vivo and in vitro when peripheral melatonin was high and thyroxine low in plasma of male Perdicula asiatica during reproductively inactive phase. During this phase exogenous thyroxine (4 μg/100 g. Bwt./day) and melatonin (25 μg/100 g. Bwt./day) increased immune parameters (spleen weight, total leukocyte count, lymphocyte count, percent stimulation ratio) and increased splenocyte density in spleen. In vitro l-thyroxine (10−6 M/ml) supplementation decreased the splenocyte proliferation which was reversed by melatonin (500 pg/ml) supplementation. In vivo l-thyroxine showed immunoenhancing effect while in vitro it decreased the splenocyte proliferation presenting a differential effect. In the absence of internal physiological conditions of the birds, T4 showed a negative effect on splenocytes proliferation in vitro when treated alone. However, melatonin maintained its lymphoproliferative effect under both conditions. Thus, avian splenocyte exposed to different hormonal conditions in vitro might have produced different signal peptides other than in vivo, thereby making the result different.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: General and Comparative Endocrinology - Volume 145, Issue 3, February 2006, Pages 215–221
نویسندگان
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