کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2804116 1156848 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Impact of inflammatory markers on the relationship between sleep quality and incident cardiovascular events in type 2 diabetes
ترجمه فارسی عنوان
تاثیر مارکرهای التهابی بر رابطه بین کیفیت خواب و حوادث قلب و عروق در دیابت نوع 2
کلمات کلیدی
دیابت نوع 2، خواب ضعیف بیماری قلب و عروقی، شاخص کیفیت خواب پیتسبورگ، سازندگان التهابی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی

AimsTo analyze relevance of sleep quality with CVD in T2D patients and determine whether inflammation prompted by poor sleep has impact on the CVD.Methods332 T2D patients were recruited and their sleep qualities were evaluated by PSQI. The patients with PSQI score > 7 were in the poor sleep group, and the others were in the good sleep group. Plasma samples of the patients were obtained to measure inflammatory markers. Correlation analyses and regression analyses were performed to examine the cross-sectional relationships among the poor sleep, inflammatory markers and CVD.ResultsThe morbidity of CVD was significantly higher in the poor sleep patients compared to the good sleep patients (P = 0.000). PSQI score ORs were both > 1 for CVD in model 1 and model 2 (P < 0.05). PSQI score were positively related to IL-6 and ICAM-1(P < 0.05), negatively to FBI (P < 0.05), but not related to CRP in linear regression models. Multiple logistic regression analysis showed IL-6 and ICAM-1, but not FBI and CRP, were related to CVD (P < 0.05).ConclusionsPoor sleep is regarded as a plausible risk factor for CVD in T2D patients, and may be mediated by certain inflammatory markers.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Diabetes and its Complications - Volume 29, Issue 7, September–October 2015, Pages 882–886
نویسندگان
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