کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2804383 | 1156869 | 2013 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Serum Vascular Adhesion Protein-1 correlates with vascular endothelial growth factor in patients with type II diabetes Serum Vascular Adhesion Protein-1 correlates with vascular endothelial growth factor in patients with type II diabetes](/preview/png/2804383.png)
AimsTo study serum levels of soluble vascular adhesion protein (sVAP)-1 in type II diabetic patients with retinopathy.MethodsSerum samples were obtained from 53 consecutive patients, including 14 cases with non-angiogenic ocular diseases, i.e., epiretinal membrane (ERM) and idiopathic macular hole (MH), 19 cases with age-related macular degeneration (AMD), and 20 cases with diabetic retinopathy (DR). Protein levels of sVAP-1, intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1, and vascular endothelial growth factor (VEGF) were determined by enzyme-linked immunosorbent assay. Enzymatic activity of semicarbazide-sensitive amine oxidase (SSAO) was also measured.ResultsSerum level of sVAP-1 showed a moderate correlation with SSAO activity in all cases. Patients with DR had higher levels of serum sVAP-1 than subjects with ERM and MH, or those with AMD; however, severity of DR is not related to the serum levels of sVAP-1. Serum sVAP-1 correlated positively with VEGF in patients with DR, but not in those with ERM and MH, or those with AMD. Neither soluble ICAM-1 nor VCAM-1 correlated with VEGF, even in subjects with DR.ConclusionThe current data demonstrate the elevated serum levels of sVAP-1 and correlation between sVAP-1 and VEGF in patients with type II diabetes.
Journal: Journal of Diabetes and its Complications - Volume 27, Issue 2, March–April 2013, Pages 162–166