کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2813784 1569474 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New discoveries in schizophrenia genetics reveal neurobiological pathways: A review of recent findings
ترجمه فارسی عنوان
اکتشافات جدید در ژنتیک اسکیزوفرنی مسیرهای عصبی را نشان می دهد: بررسی یافته های اخیر
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
چکیده انگلیسی

Schizophrenia research has undergone a recent transformation. By leveraging large sample sizes, genome-wide association studies of common genetic variants have approximately tripled the number of candidate genetic loci. Rare variant studies have identified copy number variants that are schizophrenia risk loci. Among these, the 3q29 microdeletion is now known to be the single largest schizophrenia risk factor. Next-generation sequencing studies are increasingly used for rare variant association testing, and have already facilitated identification of large effect alleles. Collectively, recent findings implicate voltage-gated calcium channel and cytoskeletal pathways in the pathogenesis of schizophrenia. Taken together, these results suggest the possibility of imminent breakthroughs in the molecular understanding of schizophrenia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medical Genetics - Volume 58, Issue 12, December 2015, Pages 704–714
نویسندگان
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