کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2814020 1569507 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Characterization and meiotic segregation of a supernumerary marker chromosome in sperm of infertile males: Case report and literature review
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Characterization and meiotic segregation of a supernumerary marker chromosome in sperm of infertile males: Case report and literature review
چکیده انگلیسی

This couple presented with a 4-year history of primary infertility. The male partner was found to have oligoasthenozoospermia. A supernumerary marker chromosome (SMC) was found. Fluorescent in situ hybridization (FISH) analyses showed that the SMC was a heterochromatic dicentric marker derived from chromosome 22. Further FISH procedures showed the rate of unbalanced spermatozoa containing one chromosome 22 and the SMC to be 15.6%. Due to the low risk of fetal chromosomal imbalance linked to the paternal SMC and the risk of miscarriage linked to the amniocentesis, the couple declined prenatal diagnosis. A healthy newborn baby was obtained after ICSI.


► A supernumerary marker chromosome derived from chromosome 22 was found in a oligoasthenozoospermic man.
► Rate of unbalanced spermatozoa was 15.6%.
► A healthy newborn baby was obtained after ICSI.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medical Genetics - Volume 55, Issue 12, December 2012, Pages 743–746
نویسندگان
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