کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2815304 1159864 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prediction of sumoylation sites in proteins using linear discriminant analysis
ترجمه فارسی عنوان
پیش بینی مکان های مخلوط کردن در پروتئین با استفاده از تجزیه و تحلیل خطی جدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
چکیده انگلیسی


• AAIndex, position-specific amino acid propensity and modification of composition of k-space amino acid pairs were used to feature construction.
• 178 features were selected as the optimal features according to the MCC values in 10-fold cross validation.
• Linear Discriminant Analysis was the first applied in the Sumoylation prediction.
• The accuracy was 86.92% in the benchmark dataset.

Sumoylation is a multifunctional post-translation modification (PTM) in proteins by the small ubiquitin-related modifiers (SUMOs), which have relations to ubiquitin in molecular structure. Sumoylation has been found to be involved in some cellular processes. It is very significant to identify the exact sumoylation sites in proteins for not only basic researches but also drug developments. Comparing with time exhausting experiment methods, it is highly desired to develop computational methods for prediction of sumoylation sites as a complement to experiment in the post-genomic age. In this work, three feature constructions (AAIndex, position-specific amino acid propensity and modification of composition of k-space amino acid pairs) and five different combinations of them were used to construct features. At last, 178 features were selected as the optimal features according to the Mathew's correlation coefficient values in 10-fold cross validation based on linear discriminant analysis. In 10-fold cross-validation on the benchmark dataset, the accuracy and Mathew's correlation coefficient were 86.92% and 0.6845. Comparing with those existing predictors, SUMO_LDA showed its better performance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 576, Issue 1, Part 1, 15 January 2016, Pages 99–104
نویسندگان
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