Compositional features are potentially involved in the regulation of gene expression of tumor suppressor genes in human tissues

• There are correlations between expression level of TS genes and gene compositional features.
• Some of the protein features have correlations with expression level of TS genes.
• Some of the correlations between expression level and compositional features are common between tissues.

Different mechanisms regulate the expression level of tissue specific genes in human. Here we report some compositional features such as codon usage bias, amino acid usage bias, codon frequency, and base composition which may be potentially related to mRNA amount of tissue specific tumor suppressor genes. Our findings support the possibility that structural elements in gene and protein may play an important role in the regulation of tumor suppressor genes, development, and tumorigenesis. The data presented here can open broad vistas in the understanding and treatment of a variety of human malignancies.