کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2816678 | 1159949 | 2014 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Association of MEP1A gene variants with insulin metabolism in central European women with polycystic ovary syndrome Association of MEP1A gene variants with insulin metabolism in central European women with polycystic ovary syndrome](/preview/png/2816678.png)
• The MEP1A rs17468190 (G/T) is associated with insulin metabolism in PCOS women.
• The MEP1A rs17468190 (G/T) might contribute to the pathogenesis of PCOS.
• The MEP1A rs17468190 (G/T) may be a disease modifying factor of PCOS.
• The MEP1A rs17468190 (G/T) could be of clinical relevance for PCOS treatment.
• The MEP1A rs17468190 (G/T) could contribute to patients' specific therapy schemes.
Polycystic ovary syndrome (PCOS) shows not only hyperandrogenemia, hirsutism and fertility problems, but also metabolic disturbances including obesity, cardiovascular events and type-2 diabetes. Accumulating evidence suggests some degree of inflammation associated with prominent aspects of PCOS. We aimed to investigate the association of genetic variants 3′UTR rs17468190 (G/T) of the inflammation-associated gene MEP1A (GenBank ID: NM_005588.2) with metabolic disturbances in PCOS and healthy control women.Genetic variants rs17468190 (G/T) of MEP1A gene were analyzed in 576 PCOS women and 206 controls by using the Taqman fluorogenic 5′-exonuclease assay. This polymorphism was tested for association with anthropometric, metabolic, hormonal, and functional parameters of PCOS.There was a borderline significant difference in genotype distribution between PCOS and control women (p = 0.046). In overweight/obese PCOS patients, the variants rs17468190 (G/T) in the MEP1A gene are associated with glucose and insulin metabolism. In a dominant model, the GG genotype of the MEP1A gene was more strongly associated with insulin metabolism in overweight/obese PCOS women (body mass index, BMI > 25 kg/m2), than in GT + TT genotypes. The MEP1A GG-carriers showed a significantly increased homeostatic model assessment — insulin resistance (HOMA-IR) (p = 0.003), elevation of fasting insulin (p = 0.004) and stimulated insulin (30 min, p < 0.001; 60 min, p = 0.009; 120 min, p = 0.009) as well as triglyceride (p = 0.032) levels.MEP1A is a possible target gene for disease modification in PCOS. It might contribute to the abnormalities of glucose metabolism and insulin sensitivity and serve as a diagnostic or therapeutic target gene for PCOS.
Journal: Gene - Volume 537, Issue 2, 10 March 2014, Pages 245–252