کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2817331 1159980 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Methylenetetrahydrofolate reductase 677TT genotype might be associated with an increased lung cancer risk in Asians
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Methylenetetrahydrofolate reductase 677TT genotype might be associated with an increased lung cancer risk in Asians
چکیده انگلیسی

BackgroundThe association between methylenetetrahydrofolate reductase (MTHFR) 677C > T polymorphism and lung cancer risk has been studied in various populations with conflicting results. The aim of this study was to assess the association strength by a meta-analysis of published studies.MethodsWe searched PubMed and Chinese Biomedical (CBM) databases for relevant literatures published by July 18, 2012. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated to assess the strength of the association.ResultsA total of 20 studies comprising 11,653 cases and 12,032 controls were included in the final meta-analysis. Using the random effect model, we found that MTHFR 677TT variant genotype was associated with an increased lung cancer risk (OR = 1.26, 95% CI = 1.05–1.50, P = 0.011 for TT vs. CC; OR = 1.19, 95% CI = 1.03–1.37, P < 0.001 for TT vs. CC + CT; OR = 1.11, 95% CI = 1.02–1.22, P = 0.017 for T allele vs. C allele). In the further stratified analyses, the increased lung cancer risk was found in Asian subjects (OR = 1.31, 95% CI = 1.01–1.71, P = 0.045 for TT vs. CC; OR = 1.17, 95% CI = 1.00–1.38, P = 0.048 for TT vs. CC + CT). There were no evidences for obvious publication bias in the overall meta-analysis and Asian subjects.ConclusionsMTHFR 677TT genotype might increase the susceptibility of lung cancer, especially in Asians.


► We quantitatively summarized 20 studies by means of meta-analysis.
► The relation of MTHFR C677T polymorphism with lung cancer has been clarified.
► We found an association of MTHFR C677T polymorphism and lung cancer risk.
► The MTHFR 677TT genotype might increase lung cancer risk, especially in Asians.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 515, Issue 1, 15 February 2013, Pages 214–219
نویسندگان
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