Meta-analysis of genetic association of chromosome 9p21 with early-onset coronary artery disease

PurposeA number of studies reported on associations of single nucleotide polymorphisms (SNPs) present in chromosome 9p21 with early-onset coronary artery disease (CAD). The present study was then undertaken to perform a meta-analysis of all the results published to date.MethodsAll studies of the 9p21 association with early-onset CAD that were published between 2007 and 2012 were retrieved from the PubMed database. RevMan 5.0 software was used to perform meta-analysis of the data that fulfilled the criteria for our meta-analysis. The effect size of four SNPs in the 9p21 region on early-onset CAD risk was assessed based on the odds ratios (ORs) with calculation of 95% confidence interval (CI).ResultsA total of 7123 subjects from 7 case–control studies were genotyped. Meta-analysis demonstrated disease association for rs2383207 (OR = 0.79, 95% CI 0.71–0.88, P < 0.0001), rs2383206 (OR = 1.17, 95% CI 1.10–1.25, P < 0.00001), rs10757278 (OR = 1.28, 95% CI 1.15–1.42, P < 0.00001), and rs10757274 (OR = 1.17, 95% CI 1.08–1.33, P = 0.02).ConclusionGenetic variation in the chromosome 9p21 region may contribute to the etiology of early-onset CAD although their effect size is rather small.

► First report on meta-analysis of genetic association of 9p21 with early-onset CAD
► A total of 7123 subjects were included to perform the meta-analysis.
► Genetic variations in 9p21 region contribute to the etiology of early-onset CAD.
► This work is important to better understand molecular mechanism of early-onset CAD.