Quantitative evaluation of common polymorphism (rs1801282) in the PPARγ2 gene and hypertension susceptibility

The peroxisome proliferator-activated receptor-γ2 (PPARγ2) gene has been implicated in the etiology of hypertension. However, the results have been inconsistent. In this study, a meta-analysis was performed to assess the association of PPARγ2 rs1801282 polymorphism with hypertension risk. Published literature from PubMed, Embase databases, CNKI and Wanfang Data were retrieved. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed- or random-effects model. Eight studies (1865 cases and 1416 controls) for rs1801282 polymorphism were identified. The results suggested that rs1801282 polymorphism Ala allele might be protective for hypertension among East Asians (Ala/Ala + Pro/Ala vs. Pro/Pro: OR = 0.63, 95%CI 0.46–0.86) but not among Caucasians (Ala/Ala + Pro/Ala vs. Pro/Pro: OR = 0.72, 95%CI 0.38–1.38). The results indicated the significant association of PPARγ2 rs1801282 polymorphism with hypertension susceptibility among East Asians.

► The PPARγ2 gene has been implicated in the etiology of hypertension.
► Eight studies (1865 cases and 1416 controls) for rs1801282 variant were identified.
► There was a significant association of PPARγ2 variant with hypertension risk.