کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2819051 | 1569902 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
UTR dinucleotide simple sequence repeat evolution exhibits recurring patterns including regulatory sequence motif replacements
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کلمات کلیدی
cpsHCESTR, Short Tandem RepeatsARE, AU-rich elementsuntranslated region.SSR, simple sequence repeat - SSR، توالی ساده تکرار می شودDevelopment - رشدNervous system - سیستم عصبیAU-rich element - عنصر غنی AUPost-transcriptional regulation - مقررات پست مدرنUTR یا untranslated regions - منطقه ترجمه نشدهMicrosatellites - میکرو ستارهARE - هستند
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
New genome sequence information was used to study evolution of 22 dinucleotide simple sequence repeat (diSSR) sites whose upstream flanking sequences were shown to be conserved comparing Homo sapiens with the marsupial, Monodelphis domestica. Among mammals, most of these diSSR sites were conserved both upstream and downstream of the diSSR. However, individual diSSRs were frequently replaced by alternative repeats. Conserved among mammals examined, the Vsnl1 gene's 3â² UTR-localized (AC)n repeat replaced an A-rich tract in non-mammalian vertebrates examined. The Sema6D gene's (GT)n was also well conserved among mammals examined. Such conservation provides evidence of a functional role. The UTR-localized diSSRs of other genes evolved by replacing alternative diSSRs, by replacing mononucleotide-rich tracts and, in fewer cases, by expansion from short repeating sequences. Extension of the study to less conserved diSSR sites revealed that some diSSRs replaced post-transcriptional regulatory motifs, such as AU-rich elements (AREs) and C-rich tracts. The Mtap2 gene's UTR-localized (AC)n was located within a known dendritic targeting element. These evolutionary replacements suggest that some diSSRs belong to a broader group of weak-folding repetitive sequences with potential regulatory roles.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 429, Issues 1â2, 15 January 2009, Pages 80-86
Journal: Gene - Volume 429, Issues 1â2, 15 January 2009, Pages 80-86
نویسندگان
Donald E. Riley, John N. Krieger,