کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2820101 1160166 2006 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Repertoire of mouse ectodysplasin-A (EDA-A) isoforms
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Repertoire of mouse ectodysplasin-A (EDA-A) isoforms
چکیده انگلیسی

Mutations in ectodysplasin-A (EDA) cause loss of hair, sweat glands, and teeth in man and mouse. Isoform EDA-A1 protein shows partial rescue of the affected Tabby mouse phenotypes, suggesting that other isoforms may be required for full function. We describe genomic structure for five EDA isoforms, EDA-A1′, A5, A5′, A6, and A6′, in addition to the previously known EDA-A1, A2, A3, and A4. The novel isoforms together account for ∼12% of total EDA transcripts. The most different, EDA-A6 and A6′, which lack the critical domain for interaction with NF-κB-activating receptors, were nevertheless confirmed to be present in mouse and human skin tissue. Other isoforms, EDA-A5 and A5′, for example, activated NF-κB through receptors EDAR and XEDAR. These properties make new isoforms candidates for modulators of EDA function.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 371, Issue 1, 12 April 2006, Pages 42–51
نویسندگان
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