کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2822061 1570120 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genome-wide expression analysis comparing hypertrophic changes in normal and dysferlinopathy mice
ترجمه فارسی عنوان
تجزیه و تحلیل بیان ژنوم در مقایسه با تغییرات هیپرتروفی در موش های نرمال و دیسفرلینوپاتی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
چکیده انگلیسی

Because myostatin normally limits skeletal muscle growth, there are extensive efforts to develop myostatin inhibitors for clinical use. One potential concern is that in muscle degenerative diseases, inducing hypertrophy may increase stress on dystrophic fibers. Our study shows that blocking this pathway in dysferlin deficient mice results in early improvement in histopathology but ultimately accelerates muscle degeneration. Hence, benefits of this approach should be weighed against these potential detrimental effects. Here, we present detailed experimental methods and analysis for the gene expression profiling described in our recently published study in Human Molecular Genetics (Lee et al., 2015). Our data sets have been deposited in the Gene Expression Omnibus (GEO) database (GSE62945) and are available at http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE62945. Our data provide a resource for exploring molecular mechanisms that are related to hypertrophy-induced, accelerated muscular degeneration in dysferlinopathy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Genomics Data - Volume 6, December 2015, Pages 253–257
نویسندگان
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