کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2822949 1570160 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Phylodynamics of DENV-1 reveals the spatiotemporal co-circulation of two distinct lineages in 2013 and multiple introductions of dengue virus in Goiás, Brazil
ترجمه فارسی عنوان
پویایی های چندگانه DENV-1 نشان دهنده گردش مشترک فضایی موقت دو خط مجزا در سال 2013 و چندین معرفی از ویروس دنگی در Goiás، برزیل
کلمات کلیدی
نوع ویروس دنگ ویروس 1؛ خطوط؛ ژنوتیپ V؛ پویایی های چندگانه؛ فیلوژوگرافی؛ فیلوژنی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک بوم شناسی، تکامل، رفتار و سامانه شناسی
چکیده انگلیسی

Dengue virus type 1 (DENV-1) was the first serotype introduced in Brazil, during in the 1980s. Since then, this virus has spread in the Brazilian territory, causing several outbreaks. In 2013 the highest number of dengue cases was notified, when compared to the previous years in Brazil, and the state of Goiás reported over 160 thousand cases. In this study, we aimed to present the Phylodynamics of DENV-1 isolates from the state of Goiás, Brazil, during 2013 outbreak, based on the envelope gene (E) sequences. Phylogenetic analysis revealed that Brazilian DENV-1 isolates are grouped together with viruses from genotype V in two distinct lineages (lineage I and lineage II) reflecting co-circulation. Phylogeographic analyses showed that these lineages were introduced in different moments in Goiás, Brazil, using distinct routes, likely originated from the Caribbean. Lineage I was first introduced coming from Rio de Janeiro (2007–2012), followed by the introduction from Argentina (2010 − 2013). Lineage II was introduced in a single moment from Rio de Janeiro and this clade has existed since 2007–2010. The different viral introduction events demonstrate the viral dispersion process with neighboring regions, which is essential for the maintenance of outbreaks and introduction of new emerging viruses. In conclusion, obtained data reveals the importance of continuous molecular surveillance of this virus in different regions, providing a better understanding of DENV-1 circulation, considering the evolutionary and virus spread patterns.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Infection, Genetics and Evolution - Volume 43, September 2016, Pages 130–134
نویسندگان
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