کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2823096 1161371 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pandemic (H1N1) 2009 virus revisited: An evolutionary retrospective
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک بوم شناسی، تکامل، رفتار و سامانه شناسی
پیش نمایش صفحه اول مقاله
Pandemic (H1N1) 2009 virus revisited: An evolutionary retrospective
چکیده انگلیسی

The pandemic (H1N1) 2009 virus is unique in many aspects, especially in its genetics and evolution. In this paper, we examine the molecular mechanisms underlying the evolution of this novel virus through a comprehensive bioinformatics analysis, and present results in the context of a review of the literature. The pandemic virus was found to arise from a reassortment of two swine viruses, each of which ultimately arose from interspecies transmission. It experienced fast evolutionary rates and strong selection pressures, diverging into two different clusters at the early pandemic stage. Cluster I became extinct at the end of 2009 whereas Cluster II continued to circulate at much lower rates in 2010. Therefore, on August 10 of 2010 the WHO declared the end of the pandemic. Important mutations associated with host specificity, virulence, and drug resistance were detected in the pandemic virus, indicating effective transmission and increased severity in humans. Much has been learned about the evolutionary dynamics of this pandemic virus; however, it is still impossible to predict when the next pandemic will occur and which virus will be responsible. Improved surveillance at different levels (both national and international) and in different hosts (especially in swine) appears to be crucial for early detection and prevention of future influenza pandemics.


► Review of the literature pertaining to pandemic (2009) H1N1.
► Comprehensive bioinformatics analysis of unique H1N1pdm sequences from 4/09 to 4/10.
► Molecular evolutionary dynamics of pandemic (2009) H1N1.
► Conclusions on likely source/causative factors leading to creation of H1N1pdm.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Infection, Genetics and Evolution - Volume 11, Issue 5, July 2011, Pages 803–811
نویسندگان
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