کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2823099 | 1161371 | 2011 | 10 صفحه PDF | دانلود رایگان |
Skin, the largest human organ, is a complex and dynamic ecosystem inhabited by a multitude of microorganisms. Host demographics and genetics, human behavior, local and regional environmental characteristics, and transmission events may all potentially drive human skin microbiota variability, resulting in an alteration of microbial community structure. This alteration may have important consequences regarding health and disease outcomes among individuals. More specifically, certain diversity patterns of human microbiota may be predictive or diagnostic of disease. The purpose of this review is to briefly describe the skin microbiota, outline the potential determining factors driving its variability, posit the likelihood of an association between the resulting microbial community structure on the skin with disease outcomes among individuals, and finally, to present some challenges and implications for studying the skin microbiota.
► We review the skin microbiota and its related methodological issues.
► Host factors, behavior, environment, and transmission influence microbial community structure.
► Human microbial communities impact health and disease.
► We present a conceptual framework to explain the mediation of skin microbiota.
Journal: Infection, Genetics and Evolution - Volume 11, Issue 5, July 2011, Pages 839–848